Abstract
Herpes zoster (HZ) is caused by reactivation of the latent varicella zoster virus, which is present due to an earlier varicella infection. Although factors causing HZ reactivation are still not well known, it usually occurs in immunocompromised individuals. A 23-year-old male patient presented with a 6-month history of ulcerated lesions in the oral mucosa and perioral region. The medical history included congenital immunodeficiency. Clinical examination revealed an extensive ulcer on the buccal mucosa extending to the skin. The diagnostic hypothesis was herpetic ulceration, and an incisional biopsy was performed. The diagnosis of HZ manifestation was confirmed, and the patient was initially treated with acyclovir (800 mg 5×/day), without clinical response. Intravenous administration of acyclovir resulted in partial healing of the skin ulceration. The patient was then treated with ganciclovir (250 mg 12/12 hours), which resulted in complete healing of the skin lesion, although some ulcerations were observed on the hard palate. Despite the various treatments, the patient died.
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