Abstract
Herpes simplex virus replication compartments: From naked release to recombining together.
Highlights
Amplification of viral genomes is key to successful infection and spread
Because HSV replicates in the nucleus, interactions at sites of viral replication determine outcomes of infection, and interactions between viral genomes and the complex nuclear environment contribute to efficient infection
Using dual-color fluorescence in situ hybridization (FISH) for pseudorabies virus (PRV) [6] and Herpes simplex virus 1 (HSV-1) [7], we showed that coinfecting herpesviruses’ replication compartments (RCs) are mostly maintained in separate territories (Fig 2)
Summary
University of Michigan Medical School, UNITED STATES. Research on HSV replication compartments is supported in the Weitzman lab by grants to MDW from the National Institutes of Health (NS082240 and AI115104) and funds from the Children’s Hospital of Philadelphia. Work between the two labs is supported by the United States-Israel Binational Science Foundation (BSF 2015395). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
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