Abstract
Background: Herpes simplex virus (HSV) esophagitis is rarely seen in immunocompetent patients. Symptoms include odynophagia, dysphagia, fever, and/or extra-esophageal herpetic lesions. A male predominance is noted with individuals being inflicted with the illness in the third to fourth decade. Although HSV esophagitis has typical punch-out lesions on endoscopy, it is very similar in appearance to cytomegalovirus (CMV) and should be confirmed by tissue biopsy. Upper gastrointestinal bleeding is a rare complication of HSV esophagitis. Treatment of HSV esophagitis in immunocompetent patients is controversial.
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