Hereditary Nonspherocytic Hemolytic Anemia with Pyruvate Kinase Deficiency.

Abstract

s1 April 1963Hereditary Nonspherocytic Hemolytic Anemia with Pyruvate Kinase Deficiency.K. R. Tanaka, M.D. (Associate), W. N. Valentine, M.D., F.A.C.P., A. S. Schneider, M.D.K. R. Tanaka, M.D. (Associate)Search for more papers by this author, W. N. Valentine, M.D., F.A.C.P.Search for more papers by this author, A. S. Schneider, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-732_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn recent years, biochemical studies have enabled a better delineation of the hereditary nonspherocytic hemolytic anemias. Nine patients (5 males and 4 females, aged 1 to 39 years), corresponding in all major respects to those classified as Type II by Selwyn and Dacie, have been studied. These patients have a Coombs-negative, nonspherocytic, hemolytic anemia of variable degree. Their red cells exhibit increased autohemolysis, not correctible (or only partially correctible) by administration of glucose, but correctible by administration of adenosine triphosphate (ATP). The age of apparent onset, clinical severity, and transfusion requirements vary considerably. Splenectomy in 4 patients has not... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Los Angeles, Calif. (CI) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPurification of human erythrocyte pyruvate kinase 1 April 1963Volume 58, Issue 4Page: 732-732KeywordsAdenosine triphosphateCellsGlucoseHemolytic anemiaPyruvateSplenectomy Issue Published: 1 April 1963 PDF downloadLoading ...