Abstract
Twenty index patients with hereditary essential tremor, and 93 first degree and 38 more distant relatives were studied at the Institute of Neurology, Queen Square, London, and Oldchurch Hospital, Romford, UK.
Highlights
MRI changes in the cerebellum and cognitive function of 13 survivors of childhood acute lymphoblastic leukemia (ALL) treated with cranial radiation of 24 Gy and intrathecal methotrexate were studied at the University of New Mexico, Albuquerque, Manitoba Cancer Foundation, Winnipeg, and University of Alberta, Edmonton
Hypoplasia of the cerebellar vermis and cognitive deficits involving visualspatial-motor coordination and memory were observed in patients compared to controls
Children treated before 5 years of age are more susceptible to post-irradiation cognitive deficits than those diagnosed at or later than 5 years
Summary
MRI changes in the cerebellum and cognitive function of 13 survivors of childhood acute lymphoblastic leukemia (ALL) treated with cranial radiation of 24 Gy and intrathecal methotrexate were studied at the University of New Mexico, Albuquerque, Manitoba Cancer Foundation, Winnipeg, and University of Alberta, Edmonton. Hypoplasia of the cerebellar vermis and cognitive deficits involving visualspatial-motor coordination and memory were observed in patients compared to controls. (Ciesielski KT et al Hypoplasia of the cerebellar vermis and cognitive deficits in survivors of childhood leukemia. The neurotoxic effects of prophylactic cranial irradiation in children with acute lymphoblastic leukemia are well documented. Children treated before 5 years of age are more susceptible to post-irradiation cognitive deficits than those diagnosed at or later than 5 years. The dose of cranial irradiation, 2400 rads, used in this study is highly toxic in young patients.
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