Abstract
Breast cancer occurs when breast cells grow out of control because they escape the fine controls that regulate cell multiplication, resulting in cell proliferation unresponsive to regulation. Most cases of breast cancer have no identifiable cause, but approximately 5% to 10% are caused by inherited genetic mutations. Although other genes are known to cause hereditary breast cancer, most studies evaluating clinical management strategies have focused on women with mutations in the BRCA1 or BRCA2 (Breast Cancer) genes. People with these mutations have a significantly increased lifetime risk of cancer compared to the general population.
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