Abstract
This study evaluated the risk of the hereditary breast and ovarian cancer (HBOC) syndrome in patients with breast cancer by using the Family History Screening 7 (FHS-7) tool, a validated low-cost questionnaire with high sensitivity able to screen the HBOC risk in the population. Women diagnosed with breast cancer (n = 101) assisted by the Unified Health System at the 8th Regional Health Municipal Office of the state of Paraná answered the FHS-7, and the results were analyzed using IBM SPSS Statistics for Windows, Version 25.0. software (IBM Corp., Armonk, NY, USA). The risk of HBOC was 19.80% (n = 20). Patients at risk exhibited aggressive tumor characteristics, such as high-grade tumors (30%), presence of angiolymphatic emboli (35%), and premenopausal at diagnosis (50%). Significant associations between the prevalence of high-grade tumors were observed in women younger than 50 years at diagnosis with HBOC (p = 0.003). Our findings suggest a possible family inheritance associated with worse clinical features in women with breast cancer in this population, indicating that HBOC investigation can be initially performed with low-cost instruments such as FHS-7.
Highlights
Breast cancer is the major cause of women’s death in the world
This study evaluated the risk of the hereditary breast and ovarian cancer (HBOC) syndrome in patients with breast cancer by using the Family History Screening 7 (FHS-7) tool, a validated low-cost questionnaire with high sensitivity able to screen the HBOC risk in the population
Our findings suggest a possible family inheritance associated with worse clinical features in women with breast cancer in this population, indicating that HBOC investigation can be initially performed with low-cost instruments such as FHS-7
Summary
Breast cancer is the major cause of women’s death in the world. Age at diagnosis under 50 years old, pre-menopausal status, and being overweight at the time of diagnosis represent independent risk factors for the disease.[6] In comparison to luminal subtypes, that have estrogen and/or progesterone receptors, triple-negative (negative for all receptors) and human epidermal growth factor receptor 2 -positive (HER-2) breast cancers usually present high proliferation rates and are considered more aggressive tumors.[5] High histological grade, lymph node involvement, and presence of angiolymphatic emboli are prognostic factors.[7] Young women (under 35 years old) with inherited breast cancer usually presents, worse disease characteristics, such as triple-negative tumors, which have few therapeutic options and low survival rates.[8,9]
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