Abstract
Currently available data on aggregations of coronary heart disease among relatives have been reviewed, and the interrelation-ships between genetic and environmental factors responsible for familial predispositions toward coronary atherosclerosis have been discussed. Although the evidence suggests a definite but not striking tendency for coronary disease to cluster in families, a quantitative assessment of the relative importance of familial influences in the genesis of these disorders is not possible at the present time. The first step toward the solution of the methodological problems involved lies in the recognition of their nature. It is suggested that the true extent of familial aggregations of coronary heart disease can only be estimated with assurance on the basis of long-term, rather than one-time, studies of families representative of the population at large.
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