Abstract
A pregnant woman diagnosed with type 1 angioedema seeks care at a public hospital for planning the delivery. This report presents ways to prevent and manage an acute HAE crisis during childbirth and early postpartum without the availability of first-line medications, such as plasma-derived human C1-INH concentrate.
Highlights
IntroductionIn 2018, she added oxandrolone, a second line prophylaxi medication, interspersing with Danazol every 6 months, with clinical control of the crisis
A pregnant woman diagnosed with type 1 angioedema seeks care at a public hospital for planning the delivery
Hereditary angioedema (HAE) is a rare autosomal dominant disease caused by a http://creativecommons.org/licenses/by/4.0/ disorder of C1-inhibitor (C1-INH) [1], which regulates the generation of brady
Summary
In 2018, she added oxandrolone, a second line prophylaxi medication, interspersing with Danazol every 6 months, with clinical control of the crisis. Both medications act suppressing pituitary output of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) and reduce attacks associated with hereditary angioedema by increasing levels of C4 component of complement. The last crisis during the pregnancy was at 33 weeks of gestational age She had uncomplicated prenatal care, except light crises of HAE as told. Aware of the risks of breastfeeding and not using prophylaxis, she was advised in case of crises to use epsilon-aminocaproic acid 500 mg/day and to suspend breastfeeding for the 2 hours after using the medication (half-life time).
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