Abstract
Elevated serum tryptase level supports the diagnoses of anaphylactic reactions and mast cell (MC) disorders, and is a marker of increased MC burden, activation, and degranulation.1 Recently, Lyons et al2 described hereditary alpha tryptasemia (HAT) as an autosomal dominant condition characterized by an increased copy number of the TPSAB1 gene, encoding for alpha tryptase, and mild-to-moderate elevated basal serum tryptase levels. Patients with HAT were described to present with urticaria, dysautonomia, and gastrointestinal symptoms.
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