Abstract
Introduction. The COVID-19 pandemic was announced by WHO in February 2020. In the Kaliningrad region, the first case (imported) was registered in early March 2020, the beginning of the epidemic increase fell on the 14th week. 2020, and the peak incidence was reached in the 22nd week of the year, after which there was a steady decrease in the number of cases. The study of population immunity was carried out at the 32nd week during the period of the lowest level of intensity of the epidemic process.Purpose of the study. Assessment of the assessment of the level of population immunity to the SARS-CoV-2 virus among the population of the Kaliningrad region during the period of the epidemic incidence of the population of COVID-19.Materials and methods. The study was carried out as part of the first stage of the Rospotrebnadzor program to assess population immunity to SARS-CoV-2 among the population of the Russian Federation. The selection of volunteers for the study was carried out by a questionnaire survey and subsequent randomization. The analysis includes the results of a survey of 2675 people. The number of volunteers in age groups ranged from 314 to 493 people. The results obtained were processed by the methods of variation statistics.Results. The results obtained showed that the average seroprevalence in the population was 50.2%, while the highest seroprevalence was found in the child age group 1-17 years (66.9%) and among persons aged 18-29 (57.0). No significant gender differences were found (men – 48,3 ± 1,6%, women – 51,1 ± 1,1%). The distribution of the proportion of seropositive people in the settlements of the region varied from 33,9% to 59.6%. The largest share of seroprevalence in the representative samples was found among people engaged in art / creativity (55,3%), the smallest – among educational workers (42,0%). Among COVID-19 convalescents, the level of humoral immunity reached 94,6%. Most of the seropositive volunteers (95,2%) did not have any symptoms of COVID-19, that is, they belonged to the category of asymptomatic carriers.Output. The results of a survey of a representative cohort of volunteers in the Kaliningrad region showed that they are characterized by a high level of population immunity, which makes it possible to expect a decrease in.
Highlights
The COVID-19 pandemic was announced by WHO in February 2020
the beginning of the epidemic increase fell on the 14th week
the peak incidence was reached in the 22nd week of the year
Summary
Полученные результаты показали, что средняя серопревалентность по популяции составила 50,2%, при этом набольшая серопревалентность была выявлена в детской возрастной группе 1–17 лет (66,9%) и среди лиц в возрасте 18–29 лет (57,0). Среди реконвалесцентов COVID-19 уровень гуморального иммунитета достиг 94,6%. Результаты обследования репрезентативной когорты волонтеров Калининградской области показали, что для них характерен высокий уровень популяционного иммунитета, позволяющий ожидать снижения напряженности эпидемического процесса. Ключевые слова: коронавирусы, SARS-CoV-2, COVID-18, заболеваемость, серопревалентность, Калининградская область, население. Понедельная заболеваемость инфекцией COVID-19 населения Калининградской области. Применяя формулу 1-1/R0, получаем значение 0,67, это значит, что активность COVID-19 начнет снижаться при достижении доли серопревалентных лиц в районе 67%. При этом основным инструментом управления эпидемического процесса является доля серопревалентных лиц в очаге инфекции. Цель исследования – изучение специфичес кого гуморального иммунного ответа и оценка уровня популяционного иммунитета к вирусу SARS-CoV-2 среди населения Калининградской области
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