Abstract
Herbal formulations marketed in India for many years providing its therapeutic benefits in health problems. Medicinal plants or their phytoconstituents are less toxic and free from side effects than synthetic drugs. However, formulation aspects of these phytoconstituents are limited due to its low solubility. Nanotechnology is a promising technique to increase the solubility of herbal drugs. This will lead to a subsequent reduction in drug dose. Nanoformulations such as nanosuspension increase the solubility of poorly soluble drugs and also have good targeting effects on different cells. The efficacy of herbal nanosuspensions evaluated using different cell lines. Here, hepatocellular carcinoma cell line (SMMC-7721), human prostate cancer cell line, human myelogenous leukemia cell line, human epithelial cell line, human breast cancer cell lines (4T1, MCF-7, and MDA-MB-453), carcinomic human alveolar basal epithelial cell line (A549), human umbilical vein endothelial cell line, human colorectal adenocarcinoma cell line (HT-29), and human epithelial carcinoma cell line (HeLa) are used in the evaluation procedures. In vitro assays help in the determination of the dose range of drugs for the activity. The present review highlights the in vitro cancer studies of herbal nanosuspensions using different cell lines.
Highlights
Herbal medicines are used all over the world due to their low toxicity and reduced side effects than synthetic drugs [1]
This study suggested that curcumin nanosuspension shows higher anticancer activity than free curcumin at the same concentration due to the presence of nano-sized particles [22]
In vitro evaluation of gambogenic acid nanosuspension against hepatocellular carcinoma cell line (HepG2) cell line Gamboge is a herbal medicine derived from Garcinia hanburyi tree, and it shows pharmacological activities such as detoxification, antiinflammatory, and parasiticide effects
Summary
Herbal medicines are used all over the world due to their low toxicity and reduced side effects than synthetic drugs [1]. This study suggested that curcumin nanosuspension shows higher anticancer activity than free curcumin at the same concentration due to the presence of nano-sized particles [22]. Antitumor effect of prepared silybin nanosuspension and free silybin was done against the PC-3 cell line in an in vitro model and evaluated at different concentrations (0.2, 1, 2, 10, 20, and 100 μg/ml ) for 12, 24, 3, and 48 h by MTT reduction assay. This study suggested that silybin nanosuspension shows a higher inhibition rate than free silybin at the same concentration [33].
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