Abstract
BackgroundThe overexpression of HER2 is associated with worse prognosis of breast cancer which responds favourably to anti-HER2 therapy. The objective of this study was to determine the frequency of HER2 and its association with clinicopathologic factors in breast cancer in Ivory Coast.MethodsThe study included 608 patients who were histologically diagnosed with invasive primary breast carcinoma. The immunohistochemistry testing for ER, PR, and HER2 was performed on the formalin fixed paraffin-embedded blocks of breast tissue of these patients. The analysis of variance and the Chi-Square Test were used to examine the association of the HER2 status with clinicopathologic prognostic features.ResultsThe average age of patients was 47 ± 11 years. Among 608 patients, 355 (58.4%) were premenopausal. Invasive ductal carcinoma of no specific type (511 cases, 84.1%) was the most frequent histologic type. Grade II tumors were 59.8%. The positivity of ER, PR, and ER/PR was 334 cases (54.9%), 252 cases (41.4%), and 356 cases (58.5%), respectively. HER2 was overexpressed in 105 cases (17.3%). The overexpression of HER2 was significantly correlated with Nottingham grade (p = 0.007). No association was observed between HER2 expression and age (p = 0.568), menopausal status (p = 0.929), histologic type (p = 0.666), ER (p = 0.137), PR (p = 0.396), and ER/PR (p = 0.134).ConclusionBreast cancer occurs in young women. HER2 status is closely related to Nottingham grade. The immunohistochemical analysis of HER2 has prognostic and therapeutic implications, and thus, contributing to efficient clinical management of patients.
Highlights
The overexpression of Human epidermal growth factor receptor 2 (HER2) is associated with worse prognosis of breast cancer which responds favourably to anti-HER2 therapy
Characteristics of patients In this study, 608 women were diagnosed with invasive primary breast carcinoma with a mean age of 47,89 ± 11 years
This study revealed that the HER2 overexpression was closely associated with the Nottingham grade, and suggesting the aggressive pattern of the HER2+ patients with breast cancer
Summary
The overexpression of HER2 is associated with worse prognosis of breast cancer which responds favourably to anti-HER2 therapy. The objective of this study was to determine the frequency of HER2 and its association with clinicopathologic factors in breast cancer in Ivory Coast. Breast cancer is the most common malignant tumour and the leading cause of death among women in the world [1, 2]. Breast cancer is the first cancer in women, followed by cervical cancer according to the Cancer Registry of Abidjan in Côte d’Ivoire [1]. HER2 is a proto-oncogene found on chromosome 17q encoding tyrosine kinase receptor located on the surface membrane of the epithelial cells of the breast [3,4,5].
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