Abstract
Sublethal doses of cadmium chloride (CdCl 2; 3 mg/kg i.V.), mercuric chloride (HgCl 2; 2 mg/kg i.v.) and sodium vanadate (6 mg/kg i.v.) were administered to normal and glutathione (GSH)-depleted mice (phorone, 250 mg/kg i.p.). In normal mice serum sorbitol dehydrogenase (SDH) activity as a measure of hepatotoxicity was elevated 24 h after treatment with CdCl 2 and HgCl 2. Following GSH depletion more pronounced increments of SDH activities were observed only after CdCl 2 treatment. No difference was seen in the exhalation of ethane by normal and GSH-depleted animals, neither in metal-treated nor in control mice, indicating that lipid peroxidation is not involved in their hepatotoxicity.
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