Abstract
Acetaminophen is commonly known as Paracetamol. It is an antipyretic drug, analgesic. It first introduced in 1955 and it cause liver toxicity, which is big issue for Patients now days also. In this work Delnix Regia and Aegle Marmeloes both the plant collected from local area Jaipur and authentify by Department of Botany, Rajasthan University, Jaipur. The authentication number is RUBL 211610 and RUBL 211611and extracted the leaves content by soxhelation process and compare them, which one is more helpful as hepatoprotective because acetaminophen drug cause toxicity in liver and for evaluation purposes different types of test like SGOT, SGPT, Total bilirubine, Total protein, molisch test, wagner test, Hager test, Benedicts test etc performed. In this work we observed that after all evaluation that Delnex Regia is more heptoprotective as compare to Aegle Marmeloes 
 Key word: Acetaminophen, Delnix Regia, Aegle Marmeloes, Hepatotoxicity
Highlights
Acetaminophen (APAP) commonly known as paracetamol (IUPAC name: N-(4-hydroxyphenyl) ethanamide).This medicine is commonly used for antipyretic purpose, pain reliever.Since1955 this drug is available as single dose or with other drug combination, this drug introduced to the market by the McNeil Laboratories in UK
Hepatotoxicity is clear that when Acetaminophen used to induce liver toxicity there is a substantial increase in enzyme activity of SGOT, SGPT, SALP and Serum Bilirubin
Ethanolic extract of Aegle marmelos has reduced the elevated levels of SGOT, SGPT, SALP and Serum Bilirubin to lesser extent compared with ethanolic extract of Delonix Regia
Summary
Acetaminophen (APAP) commonly known as paracetamol (IUPAC name: N-(4-hydroxyphenyl) ethanamide).This medicine is commonly used for antipyretic purpose, pain reliever.Since1955 this drug is available as single dose or with other drug combination, this drug introduced to the market by the McNeil Laboratories in UK. First hepatic failure case due to Acetaminophen comes in UK in 1966. APAP absorbed rapidly in gastrointestinal tract with peak concentration achieved in 90 minutes, but if food is present in stomach it may be delay the peak but nut the absorption. Half life of acetaminophen is around 2-2.5 hour. Acetaminophen is metabolized by glucronidation and sulphate, almost 30% of acetaminophen excreted by urine from body
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