Hepatotoxicity Induced by Carbon Tetrachloride in Experimental Model

Abstract

The present study is the first attempt to evaluate the hepatotoxicity induced by carbon tetrachloride (CCl4) in experimental model. It poses a significant hazard to one's health. It is also one of the leading sources of toxicity in critical organs such as the lungs, kidneys, liver, and brain. Objective: To assess the hepatotoxicity of carbon tetra chloride in albino rats. Methods: The research was conducted at the Department of Zoology, University of Okara. The experiment was conducted at the animal home of the Department of Zoology, University of Okara. There were two groups created: a control group and an experimental group. The experimental group was treated with CCl4. The rats were fed 30% diluted carbon tetrachloride with normal saline as a control group to test the harmful effect on the liver profile. This was accomplished through a 12-day trial. Sampling or dissection was done after 12 days. Rats were dissected, and their liver was punctured to obtain a blood sample and organ collection. After sampling was taken by puncturing the Rats' liver, the samples were examined by a machine called Micro-Lab 300. Results: Histopathological studies also proved that the liver of rats was damaged. The hepatotoxic dose of CCl4 also raised the serum AST, ALP, ALT, and bilirubin levels. Total levels of AST, ALP, ALT, and Bilirubin were higher than usual, indicating that CCl4 has a toxic effect on the liver profile of rats. Conclusions: This study suggested that CCl4 induced toxicity in rat liver.