Abstract
Objective: The serum transaminases document is severe elevated in a patient who was receiving Carvedilol. Case Summary: A 65-year-old Saudi man admitted to hospital with acute heart failure (EF 15%), acute liver failure and acute kidney injury. He was admitted to CCU and started treatment. Within one week the kidney and the liver function improved. After that the doctor changed Bisoprolol to Carvedilol for one day only, the laboratory tests showed elevated serum transaminases. So, discontinued Carvedilol immediately and restart bisoprolol the liver function returned to the normal within four weeks. Conclusion: Carvedilol may cause liver enzymes elevated in liver impairment patient. This reaction resolves if the patient is switched to another beta- blocker. Carvedilol is contraindication in sever hepatic impairment.
Highlights
Heart failure is a complex syndrome that can result from the heart muscle is unable to pump enough blood through to meet the body's needs for blood and oxygen
Heart failure is the main cause of hospitalization for patients over the age of 65 years[1,2,3]
Carvedilol was approved by the Food and Drug Administration in 1997 for the treatment of heart failure[4]
Summary
Heart failure is a complex syndrome that can result from the heart muscle is unable to pump enough blood through to meet the body's needs for blood and oxygen. ISSN 2393-8862 and feet, rapid or irregular heartbeat, reduced ability to exercise. It is affects around 26 million people worldwide. There are more than 6 million people in the USA. Heart failure is the main cause of hospitalization for patients over the age of 65 years[1,2,3].
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