Abstract
This study was carried out to ascertain the hepatotoxic potential of T.daniellii (T.d) and A. cordifolia (A.c). Investigations were conducted using standard methods. Oral administration of 200mg/kg aqueous leaf extracts of T.daniellii caused a non-significant increase in the activity of ALT (5.43±0.60IU/L), AST (16.93±0.26 IU/L) and ALP (160.70±1.04 IU/L) compared to the values recorded on the normal control (group I) ALT (3.84±0.16 IU/L), AST (14.19±0.52 IU/L) and ALP (157.26±0.64 IU/L). Group III administered with 200mg/kg methanolic leaf extract of T. daniellii manifested a significant elevation in the activity of ALT (13.15±0.89 IU/L), AST (22.84±0.38 IU/L) and ALP (170.40±0.44 IU/L) compared to the normal control. Similarly, groups IV and V which were orally administered with 200mg/kg aqueous and methanolic leaf extracts of A. cordifolia showed significant increase in the activity of ALT (6.32±0.33U/L), AST (17.70±0.030U/L) and ALP (161.13±0.09U/L) and ALT (7.55±0.59U/L), AST (19.35±0.26U/L) and ALP (165.38±0.35U/L) respectively compared to the values recorded on the control (group I). In conclusion, drug development protocols involving T. daniellii leaf should preferably use water as an ideal solvent. On the other hand, the hepatotocity associated with both aqueous and methanolic extracts of A. cordifolia could imply the presence of hepatotoxins in the leaf of the said plant.
Highlights
The liver which is the largest organ of the body is strategically located between the gastrointestinal tract and general circulation (Chiang, 2014)
Known as Christmas Bush is a shrubby tree of the family Acalypholdeae
Enzyme activities were determined with the aid of commercial enzyme kits manufactured by the Biorex fars company using automated analyzer device
Summary
The liver which is the largest organ of the body is strategically located between the gastrointestinal tract and general circulation (Chiang, 2014). It possesses a domed upper surface which relates wholly to the diaphragm, while its visceral surface which carries the gall bladder rests upon the stomach, upper duodenum, hepatic flexure of the colon, right kidney and suprarenal gland (Chiang, 2014). Thaumatococcus Daniellii (Benth), known as the sweet prayers plant or katemfe, grows undergrowth of forest trees throughout the hot and humid tropical rain forest and coastal zones of West Africa (Mansfeld, 1986). The leaves of the plant are used in the treatment of mhs.ideasspread.org
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