Abstract
Hepatosplenic T-cell lymphoma (HSTCL) is a rare, aggressive T- cell lymphoma that is characterized by hepatosplenic and bone marrow sinusoidal infiltration of cytotoxic T cells, usually of gamma-delta (γδ) T-cell receptor type. The diagnosis was challenging as he required an extensive investigation that ultimately showed the characteristic clinical, histopathologic, and cytogenetic features of hepatosplenic T-cell lymphoma. We report a case of 12-year-old girl patient with HSTCL and visceral leishmaniasis, presented with progressive jaundice, massive hepatosplenomegaly, and weight loss. The diagnosis was required an extensive investigation that ultimately revealed the characteristically clinical, histopathological and cytogenetic features of hepatosplenic T-Cell Lymphoma. The clinical course was aggressive and multi-agent chemotherapy are used. The importance of considering it in a differential diagnosis of hepatosplenomegaly in young girl who present with constitutional symptoms and visceral leishmaniasis without lymphadenopathy.
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