Abstract
Hepatocellular carcinoma is a malignant tumor with a very high morbidity and mortality. It has a poor prognosis due to its common infiltrating. Liver carcinogenesis is driven by genetic alterations in combination with viral and environmental factors. P53 mutations represent main genetic alteration described in hepatocellular carcinoma. Because of this, p53 gene therapy is proposed as a potential treatment. P53 tumour suppressor gene is responsible for apoptotic signals in tumour signals and thus for their uncontrolled proliferation and recurrence. New approaches to hepatocellular carcinoma treatment are needed to improve patient survival.
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