Abstract
The purpose of present study was to prepare and characterize the complex between curcumin and soya lecithin, and to evaluate its hepatoprotective activity. The curcumin-soya lecithin complex was prepared by dissolving curcumin and soya lecithin in equimolar ratio in dichloromethane and heating at 60°C for 2 h. The curcumin-soya lecithin complex was characterized by DSC, FTIR and NMR spectroscopy. The prepared complex provided a 3-fold increase in solubility of curcumin. On evaluation of in vitro intestinal permeability of curcumin across the everted sheep gut sac, the complex was found to provide the higher intestinal permeation of curcumin. On in vivo evaluation of curcumin-soya lecithin complex in paracetamol-induced hepatotoxicity in mice, it was observed that the complexed curcumin afforded a significantly higher protection against paracetamol-induced rise in serum aspartate aminotransferase and alanine aminotransferase levels as compared to pure curcumin.
Highlights
Curcumin, a naturally occurring polyphenolic phytoconstituent, is isolated from the rhizomes of Curcuma longa Linn.(Zingiberaceae)
The use of curcumin is limited by its poor aqueous solubility in acidic or neutral conditions and instability in alkaline conditions
The physical mixture of curcumin and soya lecithin provided a higher solubility of curcumin
Summary
A naturally occurring polyphenolic phytoconstituent, is isolated from the rhizomes of Curcuma longa Linn.(Zingiberaceae). The in vivo hepatoprotective activity of curcumin-soya lecithin complex was evaluated and compared with pure curcumin in paracetamol-induced hepatotoxicity in mice model. Tab. 2 compares the effect of pure curcumin and curcumin-soya lecithin complex on the paracetamol-induced rise in serum AST and ALT levels of mice.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
