Hepatoprotective Potential of Methanolic and Aqueous Extract of Chenopodium botrys against Lead-induced Toxicity

Abstract

Background: Chenopodium botrys L. is local to Europe and Asia and established in North America. The plant commonly used for the treatment of disease. The medicinal use of Chenopodium botrys is mainly due to mythology rather than scientific proof. Objectives: To evaluate the hepatoprotective potential of methanolic and aqueous extract of Chenopodium botrys against lead-induced toxicity. Materials and Methods: The aerial parts of Chenopodium botrys were extracted by the continuous hot extraction process using acetone and methanol as a solvent and the aqueous extract of the plants were obtained by the cold maceration process. Liver tissue was treated with 5 ppm Lead Acetate and 5 mg/ml of acetone methanol and aqueous extract of Chenopodium botrys. During the study, biochemical indices like lipid peroxidation (LPO), Protein levels and enzymatic activities of alkaline phosphatase (ALPase), acid phosphatase (ACPase) and succinate dehydrogenase (SDH) were measured. Results: The current study report that protein levels and enzymatic parameters of alkaline phosphatase as well as succinate dehydrogenase declined significantly while levels of lipid peroxidation and acid phosphatase increased significantly in lead acetate exposed goat liver homogenates as compared to control groups. Co-administration of herbal methanol and aqueous extract of Chenopodium botrys (5 mg/ml) along with 5 ppm lead acetate to liver homogenate exerted an ameliorative effect and maintained the studied parameters closed to control group. Conclusion: Chenopodium botrys is endowed with hepatoprotective activity. It can be taken as one candidate for the development of hepatoprotective agents because of its good safety profile.