Abstract
<p class="Abstract">Artocarpus lakoocha fruits are widely consumed as food. The study was aimed at evaluating its hepatoprotective activity and chemical constituents. The extract was analysed by HPLC for the presence of flavonoids and phenolic compounds. Hepatoprotective potential was determined in mice following 8 days of extract or silymarin (standard therapy) administration. Hepatotoxicity was induced by administration of paracetamol (500 mg/kg). The blood and liver of treated and untreated mice were collected 24 hours post-paracetamol intoxication. HPLC analysis confirmed the presence of chromatotropic acid, quercetin, gallic acid, vanillic acid, cinnamic acid, ferulic acid and kaempferol. Acute toxicity study showed no observed effect at more than 2,000 mg/kg. The fruit extract prevented the rise in liver function tests and paracetamol related histopathological alterations. The hepatoprotective activity of extract was dose-dependent. This study confirms the preventive effect of methanolic extract of monkey jack fruits against paracetamol-induced liver toxicity.</p><p class="Abstract"><strong>Video Clip of Methodology</strong>:</p><p class="Abstract">7 min 25 sec: <a href="https://www.youtube.com/v/oyuEIJc8pqU">Full Screen</a> <a href="https://www.youtube.com/watch?v=oyuEIJc8pqU">Alternate</a></p>
Highlights
Liver is a vital organ for metabolism and plays a pivotal role in detoxification and elimination of drugs
It was found that methanolic extract of A. lakoocha was dark brown in color and the %yield was 7.27%
Qualitative phytochemical analysis of fruit extract confirmed the presence of flavonoids, tannins, terpenoids, saponins, glycosides, alkaloids and steroids
Summary
Liver is a vital organ for metabolism and plays a pivotal role in detoxification and elimination of drugs. Longterm exposure to toxins produces reactive oxygen species (ROS) which may lead to oxidative stress, lipid peroxidation and cellular damage through alteration of metabolic processes in hepatocytes (Akhtar et al, 2011). Allopathic drugs can rarely stimulate the liver function (Akhtar et al, 2016a). A huge number of herbal drugs have been investigated for their ability to regenerate and protect hepatocytes (Ijaz et al, 2017; Qadir and Ahmad, 2017; Rehman et al, 2017; Ishtiaq et al, 2017; Sunil Kumar et al, 2017; Ullah et al, 2016). According to WHO, about 4 billion people use herbal medicines for primary health care (Akhtar et al, 2016c)
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