Abstract
This study was conducted to evaluate the possible protective impact of Chlorella vulgaris (C. vulgaris) on liver tissues of adult male albino rats intoxicated with deltamethrin (DLM). Thirty-two adult rats were divided into four equal groups. The control group was orally administered 0.5 mL normal saline once daily for eight weeks. The second (Chlorella group (CV)) and third (Deltamethrin group (DLM)) groups, were orally received 50 mg C. vulgaris powder/kg BW and deltamethrin 3 mg/kg BW once daily for eight weeks respectively, while the fourth group was orally received CV and DLM together, with the same previous mentioned doses and duration. DLM treated group induced a significant elevation of serum alanine aminotransferase(ALT) and alkaline phosphatase (ALP) activities. Liver oxidant/antioxidant status was altered due to DLM intoxication. Meanwhile, C. vulgaris powdernormalized the changes of ALT and ALP activities. Moreover, it improved oxidant/antioxidant status of the liver related to DLM intoxication. C. vulgaris supplementation could overcome the DLM-induced hepatotoxicity through eliminating the oxidative tissue injuries.
Highlights
Deltamethrin (DlM) is a type II synthetic pyrethroid, that inhibits humoral and cellular immune responses [1], causes thymic atrophy in mice [2], hepatotoxicity [3], hypertrophy of liver cells, significant increase in koopfer cells, blood circulation disorder and focal necrosis [4,5]
Administration of C. vulgaris concurrent with DLM induced significantly (p
The oral daily administration of 50 mg C. vulgaris powder/kg BW to adult rats for eight weeks significantly (p
Summary
Deltamethrin (DlM) is a type II synthetic pyrethroid, that inhibits humoral and cellular immune responses [1], causes thymic atrophy in mice [2], hepatotoxicity [3], hypertrophy of liver cells, significant increase in koopfer cells, blood circulation disorder and focal necrosis [4,5]. The nutritional value of CV was determined in 1950’s - 1960’s [11] and its proteins include all essential amino acids required for human growth and health [12] It is considered a functional whole food with lower cholesterol due to it provides large amounts of minerals, vitamins, and dietary fibers [13]. Chlorella vulgaris protects against the immunosuppressive effect of stress and gastric ulcer formation [14]. It showed an anti-inflammatory, immune-modulatory, hepatoprotective, antidiabetic, antihypertensive and anticancer activities [15,16,17]
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