Abstract
Problem: experimental substantiation of the prevention of disorders in the hepatobiliary system in chronic cholestasis in rats with the Minerol and Lequin complex. Aim: to study the hepatoprotective properties of the Minerol and Lequin complex in rats with cholestatic liver damage. Methods. The study was carried out on male rats of herd breeding. The animals were divided into 3 groups: group 1 – control, group 2 – animals with simulated cholestasis by ligation of the common bile duct, group 3 – animals that were subjected to prophylaxis against the background of cholestasis (administered the drugs Minerol and Lequin orally in the morning on an empty stomach for 4 months). The activity of alkaline phosphatase, alanine aminotransferase, elastase, the concentration of calcium, triglycerides and cholesterol were determined in the raw blood. The state of the liver was assessed by the organ index and the level of biochemical indicators of inflammation (MDA content, activity of urease, elastase, acid phosphatase and catalase). Main results. Experimental modeling of cholestasis in rats disrupted the functional state of the liver of animals, which was accompanied with a disturbance of lipid metabolism, an increased activity of markers of inflammation and intoxication both in the liver and in the raw blood, an increase in the organ index of the liver and a disturbance of the antioxidant-prooxidant system. Daily administration of the complex of drugs Minerol and Lequin to animals significantly improved the condition of the liver, providing hepatoprotective, antioxidant and anti-inflammatory effects. Conclusions: the obtained results of the study established the high hepatoprotective effectiveness of the complex of drugs Minerol and Lequin, on the basis of which they make it possible for us to recommend it to patients with cholestasis problems as a prevention of disorders in the hepatobiliary system.
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