Abstract
S 21 ANNUAL CONFERENCE—2013 D LI (median 282, 5). The median ALT level was 2100 IU/L(2004000). Drug-induced hepatotoxicity occurred more frequently due to the followings: chemotherapy 20 (48%), Halotan 8 (20%), antituberculous, analgetics 4 (10%), and antidiabetics 2 (5%) respectively and others 6 (12%). Out of 42 in 34 (80%) patients were diagnosed hepatocellural injury, with elevation of aminotransferase levels as predominant symptom, in the rest of them was found cholestatic injury with elevated ALP levels. Ascit was found in 10 (23%) patients, 2 (4.8%) died from acute liver failure. The recovery period of 40 patients lasted for 4-12 weeks. Conclusions: Drug-induced hepatotoxicity was 7.8% among the patients with acute hepatitis.Risk factors of drug-induced hepatotoxicity were: age, gender and large BMI/obesity.The most frequent cause of drug-induced hepatitis was chemotherapy with compatibility of several drugs. Corresponding Author. Hasmik Ghazinyan. E-mail: ghazinian@gmail.com HEPATOPROTECTIVE EFFECTS OF POLYGONUM BISTORTA (LINN) AND ITS ACTIVE PRINCIPLE AGAINST ACETAMINOPHEN -INDUCED TOXICITY IN RATS Deepak Kumar Mittal, Deepmala Joshi, Sangeeta Shukla Jiwaji University, Gwalior, India, Deen Dayal Upadhyay University,
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