Abstract
Plumbago zeylanica L. (PZ) is a folk medicine for liver damage. To further explore its mechanism of action, a rat model of liver injury induced by carbon tetrachloride (CCl4) was used to evaluate the protective effect of PZ water extract (PZE). The results showed that PZE normalized the CCl4-induced serum levels of liver function index, hyaluronic acid (HA), superoxide dismutase (SOD), malondialdehyde (MDA), and decreased the hydroxyproline (Hyp) level in liver tissue. PZE also reduced the histological injuries induced by CCl4. In conclusion, these data demonstrated the hepatoprotective activities of PZE that may be related to its antioxidant properties.
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