Abstract
Background: Nowaday’s liver diseases due to exposure of different drug molecules are very common. The aim of the present study was to investigate the effect of methanolic extract of Tribulus terrestris L (TT) against acetaminophen (AA)-induced liver damage in Wistar rats. Materials and methods: Animals were divided into five groups of six rats each. Results and discussion: Oral administration of TT (500 mg/kg) along with AA (2.5 gm/kg) showed a significant decrease in serum enzyme aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, direct bilirubin and alkaline phosphatase (ALP) levels with a decrease in total protein levels (p < 0.01). The results were comparable with silymarin (SL), a standard hepatoprotective drug. The present study reveals that the administration of TT can be beneficial for the suppression of liver damage. Based on present findings, it can be concluded that methanolic extract of TT protects the liver from AA-induced liver damage. The present study for the first time reports the hepatoprotective potential of TT in AA-induced liver damage in Wistar rats.
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