Abstract
Problem statement: Taurine, 2-aminoethanesulphonic acid is an essential amino acid. It is present at high concentrations in many tissues. It plays important roles in numerous physiological functions including conjugation with bile acids, modulation of calcium levels and maintenance of osmolarity, antioxidation and stabilization of membranes. Methotrexate (MTX), as the most disease modifying anti-rheumatic drug used for Rheumatoid Arthritis (RA), has been available for clinical use since 1951. The main scope of this study was to assessment of probable Hepatoprotective effect of taurine as it antioxidant action against oxidative stress due to methotrexate in rats. Approach: Eighty male Wistar rats, weighing 200±20 gr, were obtained from the animal breeding center of Islamic Azad University. The rats were divided into 4 equal groups of 20 animals including: 1-normal control, 2-normal rats treated with taurine, 3- taurine + methotrexate and 4-methotrexate. Results: Methotrexate-induced hepatotoxicity as reflected by elevated serum ALT, AST and GGT levels (p<0.001) and reduced serum total protein level (p<0.001). Conclusion: Taurine has a protective action against hepatotoxins and suggest that taurine may find clinical application against a variety of toxins where cellular damage is a consequence of reactive oxygen species.
Highlights
Hepatic injury both in vitro and in vivo (Pietrangelo, 1996; Baroni et al, 1998)
Functions including conjugation with bile acids, where remarkable Histopathological improvement in modulation of calcium levels and maintenance of taurine treated animals subjected to hepatotoxin was osmolarity, antioxidation and stabilization of membranes observed and this was associated with oxidative stress (Huxtable, 1992; Schrader et al, 2009)
Production of Reactive Oxygen Species (ROS). It can Methotrexate (MTX), as the most disease modifying prevent DNA damage at physiological concentrations anti-rheumatic drug used for Rheumatoid Arthritis (RA), (Heibashy et al, 2008; Messina and Dawson, 2000). has been available for clinical use since 1951
Summary
Hepatic injury both in vitro and in vivo (Pietrangelo, 1996; Baroni et al, 1998). several authors reported. 2-aminoethanesulphonic acid is an essential beneficial effects of taurine on histopathology and amino acid It is present at high concentrations in many oxidative stress parameters in a rat model of CCl4-induced tissues. It plays important roles in numerous physiological liver fibrosis (RefikMas et al, 2004; Tasci et al, 2007). GPX activity was measured by Rotruck et al (1973) method and was expressed as micromole of GSSG /minute/milligram of protein, based on blew reaction: Animals: Eighty male Wistar rats, weighing 200±20 gr, were obtained from the animal breeding center of Islamic Azad University.
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