Abstract
This study aimed to examine the hepatoprotective effects of the superfine particles of Radix Tetrastigma (SPRT) against CCl4-induced acute liver damage in rats. Animals were treated with SPRT (0.3, 0.6, and 1.2 g/kg) and showed remarkable hepatoprotection against CCl4-induced hepatotoxicity. CCl4 altered various biochemical parameters in rat liver, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), malondialdehyde (MDA), superoxide dismutase (SOD), histopathological changes, and Bax and caspase-3 expressions. SPRT significantly prevented increases in ALT and AST levels, reduced MDA level, decreased Bax and caspase-3 protein expression, enhanced SOD activity, and provided significant amelioration in the histopathological lesions. These findings suggested that SPRT has significant protective effect against acute hepatotoxicity induced by CCl4 in rats.
Highlights
Herbal medicine has been applied for disease prevention and treatment for thousands of years [1, 2]
CCl4 increased the enzymatic activity of AST and ALT compared with the control group, indicating liver damage
Administration of superfine particles of Radix Tetrastigma (SPRT) at the doses of 0.3, 0.6, and 1.2 g/kg remarkably prevented hepatotoxicity induced by CCl4 in a dose-dependent manner
Summary
Herbal medicine has been applied for disease prevention and treatment for thousands of years [1, 2]. Herbal medicine can boost immunity and protect the liver, regulate liver function, improve blood circulation in the liver, effectively repair liver cell damage, and relieve symptoms of liver diseases [3,4,5]. Radix Tetrastigma can be used as medicine, healthy food, and cosmetics because of its biological and pharmacological activities, including anti-inflammation, antivirus, antioxidation, heat-removing, detoxification, antihepatotoxicity, and analgesia [6, 7]. The root of Radix Tetrastigma contains various flavonoids, such as rutin, quercetin, and kaempferol [8, 9]. Radix Tetrastigma is a rare plant and could not be cultured.
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