Abstract
Objective: To evaluate the hepatoprotective effect of Prunus armeniaca L. (Apricot) leaf on paracetamol induced liver toxicity in rats. Method: Phytochemical investigation was performed to find active constituents of the plant extracts by the different phytochemical tests. After induction of liver toxicity, the biochemical parameters such as serum glutamic pyruvic transaminase (sGPT), serum glutamic oxaloacetic transaminase (sGOT), serum alkaline phosphatase (sALP), serum bilirubin (SB), thiobarbituric acid reactive substances (TBARS), γ-glutamyl transferase (GGT), lactate dehydrogenase (LDH), total protein (TP), albumin. The physical parameters including liver weight, body weight and histopathological changes in the liver were studied with Ursodeoxycholic acid as standard hepatoprotective agents. Results: The phytochemical investigation of the extracts showed the presence of Alkaloids, volatile oil, saponin glycosides, condensed tanins, terpenoids, steroids and flavonoids. Methanol and aqueous extract before the paracetamol administration caused a significant reduction in the values of sGOT, sGPT, sALP, TBARS, GGT, LDH TP, Albumin and sB (P<0.01) almost comparable to the Ursodeoxycholic acid. The hepatoprotective activity was confirmed by histopathological examination of the liver tissue of control and treated animals. Conclusions: The result concludes that Prunus armeniaca L. possesses the hepatoprotective effect against paracetamol induced liver toxicity in rats.
Highlights
Prunus armeniaca L. (Apricot or khubbani) belonging to family Rosaceae is an important edible, medicinal plant which is reported to contain polysaccharides, polyphenol, fatty acid, sterol derivatives carotenoids, carcinogenic glycosides, volatile component
Paracetamol was obtained from the Ranbaxy laboratory limited as a gift sample and Ursodeoxycholic acid was purchased from Embee diagnoses, Serum glutamic oxaloacetic transaminase (SGOT), Serum glutamic pyruvic transaminase (SGPT)
Hepatotoxicity is the potential complication of paracetamol, which is widely, used in general medicine and an assessment of its relative toxicity is important
Summary
Prunus armeniaca L. (Apricot or khubbani) belonging to family Rosaceae is an important edible, medicinal plant which is reported to contain polysaccharides, polyphenol, fatty acid, sterol derivatives carotenoids, carcinogenic glycosides, volatile component. The liver is vital organ of paramount significance involved in the maintenance of metabolic functions and detoxification of the exogenous and endogenous challenges like xenobiotic drugs, viral infections and chronic alcoholism. It is involved in almost all the biochemical pathways related to growth, to fight against disease, nutrient supply, energy provision and reproduction.[3] Diverse homeostatic mechanisms are affected if liver functions are impaired with serious consequences.[4] Almost all types of liver injuries may lead to hepatic failure and death. Due to excessive exposure to hazardous chemicals, sometimes the free radicals generated are so high that they overpower the natural defensive system leading to hepatic damage and cause jaundice, cirrhosis and fatty liver.[7]
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