Abstract
Sonneratia apetala fruits are edible and medicinal. Our previous report demonstrated that the S. apetala fruits extract had the hepatoprotective activity. In the study, an acidic polysaccharide named SAP-2 was isolated and purified from S. apetala fruits. The preliminary structure of SAP-2 was characterized, and its hepatoprotective effect and the mechanism of action in Nrf2 signaling pathway were also evaluated in acetaminophen (acetyl-para-aminophenol, APAP)-induced liver damaged mice. Results manifested that SAP-2 could alleviate histological changes, inhibit oxidative stress and enhance antioxidant system via activating of Nrf2 signaling pathway on APAP-induced hepatic injury. These results indicated that S. apetala fruits could be developed into a new source of potential natural antioxidant and functional food for hepatoprotection.
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