Abstract
The present study was directed to evaluate the toxi c effects of orally administered titanium dioxide naonparticles (TiO2) on liver of male albino rats a nd to evaluate the ameliorative effects of N-acetyl cysteine (NAC). Forty adult male albino rats were divided in to 4 groups; control group, NAC group, TiO2 group and TiO2/ NAC group. Rats were administered either TiO2 (1200 mg kg -1 BW) or NAC (100 mg kg -1 BW) alone or together for 9 months. Blood was taken to evaluate serum changes in GPT, GOT and MDA levels. Liver tissues were examined for changes in MDA, GSH and changes in liver histopathology. Administration of TiO2 increased serum GPT, GOT and decreased MDA levels. Co-treatment of rats with NAC and TiO2 improved such significant changes induced by TiO2 alone. Moreover, significant time dependent increase in MDA and decrease in GSH levels in liver tissues were recorded. Liver histopathol ogy showed vacuolar, hydropic degeneration and cell dea th of some hepatic cells. In conclusion, results confirmed the protective effect of NAC in ameliorat ion of the biohazard effects induced by TiO2 in rat s.
Highlights
Useful in medicine and industry, it is one of the main factors that might make them potentially dangerous to Nanosized-TiO2 is used in widespread applications such as cosmetics, food colorant and white pigment as human health
The present study was directed to evaluate the toxic effects of orally administered titanium dioxide naonparticles (TiO2) on liver of male albino rats and to evaluate the ameliorative effects of N-acetylcysteine (NAC)
Every person has been exposed to nano size TiO2 as we inhale them with every breath and consume stress of nanoparticles in the liver cells were related to the particle size and chemical compositions of them with every drink (Medina et al, 2007)
Summary
Useful in medicine and industry, it is one of the main factors that might make them potentially dangerous to Nanosized-TiO2 is used in widespread applications such as cosmetics, food colorant and white pigment as human health. Hossam Fouad Attia et al / American Journal of Pharmacology and Toxicology 8 (4): 141-147, 2013 toxicity of nanosized-TiO2 in mouse liver was demonstrated by the enhanced activities of liver damagerelated enzymes, alterations of defense-related enzymes, accumulation of naonparticles as well as histopathological changes. The literature on rodent models in vivo strongly indicates that most naonparticles tend to accumulate in the liver (Zhou et al, 2006; Kamruzzaman et al, 2007; Sadauskas et al, 2007) They have been shown to be retained by the liver leading to tissue injury in mice (Wang et al, 2007). This study evaluated the role of NAC in TiO2 induced oxidative stress and liver damage in male albino rats. N-Acetylcysteine (NAC) is a thiol-containing amino acid with free radical-scavenging properties, powerful neuroprotective and anti-oxidant actions (Atkuri et al, 2007)
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