Abstract
Objective: The aim of the present study was to investigate the hepatoprotective effect of Livplus (a polyherbal formulation) against CCl4-induced hepatotoxicity in rats. Methods: Hepatotoxicity was induced in rats by i.p. injection of CCl4 once three days for 14 days. Livplus or Silymarin was administered along with CCl4 and the biochemical parameters like aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkalinephosphatase (ALP), total bilirubin (TB), direct bilirubin, total protein (TP), gamma-glutamyl transferase (GGT), total cholesterol (TC) and triglycerides (TG) were estimated. Furthermore, biomarkers of oxidative stress such as MDA levels, Glutathione contents, SOD and catalase activity in liver tissue were estimated. Results: Treatment with Livplus significantly reduced the elevated levels of ALT, AST, ALP, bilirubin (direct and total), GGT, TC, TG and increased levels of TP compared to CCl4 control rats. The treatment with Livplus also showed a significant increase in glutathione contents, SOD and catalase activity and a decrease in MDA levels compared to CCl4 control rats. Conclusion: The finding of present study indicates that Livplus showed a potential hepatoprotective activity. These results support the traditional use of Livplus in the treatment of liver disorders.
Highlights
Liver is the most essential organ concerned with the biochemical activities in human body
The treatment with Livplus (200 mg/kg) showed a significant (P < 0.01) decrease in ALP levels as compared to CCl4 control rats, while the CCl4 control rats treated with Livplus (400 mg/kg) or silymarin (100 mg/kg) showed more significant (P
Livplus (100 mg/kg) treated rats did not show any significant difference in the levels of ALP as compared to CCl4 control group (Figure 1C)
Summary
Liver is the most essential organ concerned with the biochemical activities in human body. The most important role is to detoxicate the toxic substances.[1] The management of liver disorders is still a challenge. The search for more effective and safer hepatoprotective drugs has continued to be an important area of active research. There is no effective synthetic and conventional drugs are available, it has become a highly essential to search new drugs from herbal origin with little side effects. Herbal drugs are used for the treatment of liver diseases.[2]
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