Abstract
The hepatoprotective activities of Cestrum nocturnum (Queen of Night) was evaluated against the paracetamol induced hepatotoxicity in the mice. Aqueous ethanol (30:70) extract of plant was obtained by maceration. Results showed that aqueous ethanol extract of C. nocturnum (250 mg/kg and 500 mg/kg) produced significant (p<0.05) hepatoprotective activities against paracetamol induced liver injury in Swiss albino mice. Histopathalogical studied of liver further supported the hepatoprotective effects of C. notrunum . Phytochemical screening showed the presence of alkaloids, flavonoids, saponins, terpenes, phenolic compounds, carbohydrates and volatile oils. Most of the flavonoids have hepatoprotective activity. Therefore, the hepatoprotective activity of C. nocturnum may be due to the presence of flavonoids and phenolic components. It was concluded from the present study that aqueous ethanol extract of leaves of C. nocturnum has hepatoprotective activity against the paracetamol-induced hepatotoxicity in albino mice.
Highlights
Liver is most vital organ of the body
Paracetamol increased the normal level of liver enzymes (AST, ALT, ALP and TB) which was decreased to normal level by treatment with silymarin (Table I)
Treatment of mice with two doses of ethanol extract of C. nocturnum significantly decreased the elevated level of liver enzymes caused by paracetamol
Summary
Liver is most vital organ of the body. It play important role in the metabolisms of carbohydrate, protein and fat and detoxification of toxic chemicals and xenobiotics, secretion of bile and storage of many vitamins. Hepatic injury is caused by the production of reactive oxygen free radical during biochemical reactions (Ali et al, 2004). Scavenging of free radicals by anti-oxidants reduced the process of liver cells fibrosis (Raja et al, 2006). Most of the flavonoids have hepatoprotective activity (Ali et al, 2013). The plant has been proved to be anti-oxidant (AlReza et al, 2010). Oxidant activity of the plant appealed us to scientifically evaluate its hepatoprotective potential
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