Hepatoprotective effect of Co-enzyme Q10 in rats treated with Hydrogen Peroxide

Abstract

This study was carried out to investigate the role of Co enzyme Q10 in ameliorating the deleterious effect of oxidative stress induced by a high dose of Hydrogen peroxide.Twenty four male rats were divided into three equal groups. One served as control and Group1 treated with 0.75% H2O2 in drinking water for one month, and Group2 adminstrated orally Co Q10 with daily dose 1 mg /rat for 30 days. To assess the effect of H2O2 in drinking water with Co Q10 on the lipid profile, ALT, AST and histological changes were recorded. The present study demonstrated a clear alteration in the lipid profile of G2 and significant (P<0.05) decrease in serum TC, TAG, LDL-c and VLDL-c and increase the HDL-c . also the result exhibit significant (P<0.05) reduction in serum ALT and AST concentration in animal treated with Co Q10 comparing with the values in G1.Histological section of liver revealed that H2O2 initiate pathological lesion such aggregation mononeuclear cell, infiltration of inflammatory cell, moderate fatty change and cytoplasmic vaculation ,on the other hand, oral administration of Co Q10 completely regressed these lesion. In conclusion, the result of this study clarified the possibility of induction oxidative stress in rats in 30 days provided by 0.75% H2O2, and ameliorating the oxidative stress effect of H2O2 by administration of Co Q10.