Abstract
Abstract .Thepresentstudywasconductedtoevaluatethepossibleantioxidanteffectsofraisinaqueousandpurextractof“Karkni”on liver histology, antioxidant enzymes activities and lipid peroxide levels in liver of diabetic and normal rats. 125mg/kg of pureand aqueous extract of “Karkni” were orally administered daily to alloxan-diabetic rats for 4 weeks. Alloxan- induced diabetic ratsshowed significant increases in the levels of total protein and malondialdehyde (MDA), glutathione peroxidase (GPx), catalase(CAT) and reduced glutathione (GSH) levels were significantly decreased compared to normal rats ( p <0.05). Also, no significanteffectsonglutathioneperoxidase(GPx)activityindiabeticratswereobserved.Thechangesoftheaboveparameterstotheirnormallevels after 4 weeks of treatment were observed mainly with the pure extract. The results suggesting that pure extract suppressesthe liver tissue inflammation attenuate lipid peroxidation and can be helpful in reducing liver damage caused by alloxan-induceddiabetes.Keywords: “Karkni”, alloxan, liver, antioxidant enzymes, MDA
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
