Abstract
Hepatic cirrhosis is a neglected worldwide public health problem. Current hepatic cirrhosis treatment drugs remain inadequate and provide a poor prognosis. Research on alternative treatments has broadened to include active compounds from natural sources. Tradescantia pallida is a plant native to Mexico with high antioxidant content the activity of which has received only limited attention. The hepatoprotective activity of a Tradescantia pallida ethanol extract (TPEE) was evaluated through histopathology, and analysis of functional and biochemical parameters. Efficacy of the TPEE (50 mg/kg) was evaluated in a chronic CCl4-induced hepatotoxicity model in Wistar rats. Co-administration of the TPEE attenuated increases in alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and albumin (ALB) levels. Histopathology analysis supported the functional and biochemical observations. The TPEE upregulated genes that participate in antioxidant (NRF2 and NQO1) and antifibrotic (MMP-2 and TIMP-3) mechanisms in chronic CCl4-intoxicated rats. These findings suggest that this TPEE has beneficial hepatoprotective activity comparable to the standard hepatoprotective compound silymarin.
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