Abstract
Objective: This study aimed to determine the hepatoprotective effect of 50% ethanol extract of seagrass rhizome in terms of serum glutamicoxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) activities in paracetamol-induced rat plasma.Methods: This study included 28 male, white rats randomly divided into seven groups. Groups I and II represented the normal control and controlgroups, respectively, administered with 280 mg/kg BW of rhizome extract. Group III represented the negative control group induced by a suspensionof paracetamol (2g/kg BW). Group IV represented a positive control group administered with Hepa-Q® at a dosage of 150 mg/kg BW. Groups V, VI,and VII were administered with seagrass rhizome extract at doses of 140, 280, and 560 mg/kg BW, respectively, before paracetamol induction. Thetest material was orally administered for 17 days. On days 12–17, the rats were induced with paracetamol through the same route. On day 18, bloodsampling was performed followed by SGOT and SGPT plasma measurements.Results: Our results revealed that seagrass rhizome extracts could significantly decrease SGPT and SGOT levels in paracetamol-induced rats (p<0.05)compared with those in the negative control group.Conclusion: Thus, seagrass rhizome extracts possess the potential for development as a hepatoprotective agent.
Highlights
Liver is a vital organ for survival, and it contributes to almost every metabolic function of the body [1]
Identification of flavonoids in seagrass rhizome extract The flavonoids test on seagrass rhizome extract revealed positive results, which were indicated by the formation of yellow-orange color in the amyl alcohol layer
The serum glutamic oxaloacetic transaminase (SGOT) level in Group I in the normal range according to Girindra (1989), that is, 45.7–80.8 U/L, whereas that of Group III was above the normal range
Summary
Liver is a vital organ for survival, and it contributes to almost every metabolic function of the body [1]. The liver is involved in the synthesis, storage, and metabolism of several endogenous compounds and the clearance of exogenous compounds, including drugs and toxins from the body [2]. Damage to the liver can be overcome by preventive (hepatoprotective) and curative (antihepatotoxic) efforts [3]. Based on these backgrounds, the liver needs to be maintained to function properly. Conventional drug therapy for various liver damage diseases, such as non-alcoholic fatty liver disease and viral hepatitis, has limited efficacy and potentially adverse effects. Treatment using extracts derived from natural resources, such as plants, is considered to be the best method to maintain liver functions in the long-term without significantly inducing toxic effects [4]
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