Abstract
The purpose of this study was to evaluate the beneficial effects of organic and conventional grapevine (Vitis labrusca L.) leaf extracts in reducing hydrogen peroxide-induced stress in the liver, heart and kidney of Wistar rats by measuring lipids and proteins damages (carbonyl assay), as well as the activity of the antioxidant enzymes superoxide dismutase and catalase. The preincubation with 5 mg/mL of organic and conventional grapevine (Vitis labrusca L.) leaf extracts prevented both lipids and proteins oxidative damages in all tissues analyzed. The organic leaf extract was able to restore superoxide dismutase (kidney and liver) and catalase (heart) activities, which were modified by the treatment with H(2)O(2). The conventional extract was able to restore only the catalase activity in liver and heart tissues. The beneficial effects of the V labrusca leaf extract shown in this study could probably be important for formulating dietary supplements, as well as for developing new ingredients with improved antioxidant properties from other plant sources.
Highlights
The formation of reactive species (RS) is a natural consequence of aerobic metabolism and is associated with oxygen homeostasis, i.e. the balance between constitutive oxidants and antioxidants (Seifried et al 2007)
The aim of the present study was to investigate the protective effects of organic and conventional V. labrusca grape leaf extracts (GLET) in reducing the oxidative stress caused by H2O2 in kidney, liver and heart tissues of Wistar rats
Dietary antioxidants, including polyphenolic compounds, are considered beneficial because of their potential protective role in the pathogenesis of multiple diseases associated with oxidative stress such as cancer, inflammation and atherosclerosis (Mateos et al 2005)
Summary
The formation of reactive species (RS) is a natural consequence of aerobic metabolism and is associated with oxygen homeostasis, i.e. the balance between constitutive oxidants and antioxidants (Seifried et al 2007). Increased free radical production or reduced antioxidant defense response may give rise to increased oxidative stress (Halliwell and Gutteridge 2007), which has been associated with aging and a number of human chronic diseases such as cancer, liver, kidney and cardiovascular disorders (Seifried et al 2007, Strayo et al 2008). Vitis vinifera leaves have been traditionally used as food and for treating hypertension (Basoglu et al 2004), diarrhea, hemorrhage and varicose veins (Kosar et al 2007), as well as inflammatory disorders (Bombardelli and Morazzonni 1995, Baytop 1999), all in humans, by the traditional medicine, and for reducing blood glucose levels in diabetics rats
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