Abstract
To evaluate the hepatoprotective activity of aqueous extract of Ziziphus jujuba leaves against paracetamol-induced liver injury in experimental rats. Ziziphus jujuba has been traditionally used in the Ayurvedic system of medicine as a chief ingredient in many polyherbal formulations as antioxidant. To evaluate the antioxidant and hepatoprotective activity of aqueous leaf extract of Ziziphus jujuba leaves. Animals were pre-treated with the aqueous leaf extract for 7 days and then toxicity was induced with a single paracetamol oral injection. Pre-treatment with 150mg/kg of aqueous leaf extract of Ziziphus jujuba improved the reduced glutathione (oxidized), SOD, catalase, and peroxidase levels significantly as compared to control group. Silymarin was used as standard reference and exhibited significant hepatoprotective activity against paracetamol induced hepatotoxicity in rats. The biochemical observation was reported for rat liver sections. The results of this study strongly indicate that Ziziphus jujuba leaves have potent hepatoprotective action against paracetamol induced hepatic damage in rats. Aqueous extract was found more potent hepatoprotective. Meanwhile, in vivo antioxidant activities were also screened which were positive for aqueous extracts. On the basis of this study, we conclude that aqueous extract of Ziziphus jujuba possesses in vivo antioxidant activity and can be employed in protecting tissues from oxidative damage and stress.
Highlights
The liver is one of the largest organs in human body associated with assorted stages of metabolic and physiologic homeostasis of the organism and the preeminent site for intense metabolism and excretion
SGOT, SGPT, alkaline phosphatase (ALP), kits were purchased from Sigma, Tamilnadu, India. 5, 5'-dithiobis-2-nitrobenzoic acid (DTNB), Reduced Glutathione (GSH) and the rest of the chemicals utilized were of analytical grade and were obtained from Himedia, India
The present study had been attempted to demonstrate, “Hepatoprotective and Antioxidant role of Ziziphus jujuba leaves on paracetamol induced hepatic damage in rats” This study was done in different phases shown below: Phase I: Preliminary phytochemical analysis
Summary
The liver is one of the largest organs in human body associated with assorted stages of metabolic and physiologic homeostasis of the organism and the preeminent site for intense metabolism and excretion It has a stunning role in the maintenance, performance and regulating homeostasis of the body. Acetaminophen (N-acetyl-paminophenol, paracetamol) induced toxicity in rats is one of the extensively used experimental model to evaluate the hepatoprotective activity of plant extracts [5, 6]. It has been opinioned in recent reports that 10% of world population are affected with liver diseases along with hepatitis, alcoholic steatosis, fibrosis, liver cirrhosis and hepatocellular carcinoma. Morbidity and mortality resulting from liver diseases are a major social health complication worldwide [7]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
