Abstract
The antioxidant effects of Salvia officinalis L. hydroalcoholic extract and also its hepatoprotective effects in male rats were evaluated. Salvia officinalis L. extract was administered intraperitoneally for 28 days. Serum levels of aspartate aminotransferase, alanine transferase and alkaline phosphates in rats coadministered with both isoniazid (INH) 50 mg/kg and Salvia officinalis L. extract at 250 mg/kg showed significant reduction when compared to INH group, but administration of Salvia officinalis L. extract 250 mg/kg alone and with INH has alleviated gamma-glutamyl transferase comparing to INH receiving rats. After treatment of rats with INH 50mg/kg, severe tissue necrosis, and inflammation of central vein in liver and lymphocyte proliferation were observed; in the experimental group receiving Salvia officinalis L. extract (250 mg/kg) mild dilution in central vein and sinusoids in liver were seen. In rats coadministered with Salvia officinalis L. extract 250 mg/kg and INH low sinusoids dilution was indicated. It seems that Salvia officinalis L. extract exhibited anti-oxidative and hepatoprotective effects.
Highlights
Materials and MethodsSalvia officinalis L. plants were collected from Kordan area of Karaj in Iran. The aerial parts of plants were lyophilized and kept at −20 ̊C
Oxygen free radicals or, more generally, reactive oxygen species (ROS) are believed to be involved in the etiol
We evaluate antioxidant effects of Salvia officinalis L. hydroalcoholic extract and its therapeutic effect to counteract liver damage in male rats
Summary
Salvia officinalis L. plants were collected from Kordan area of Karaj in Iran. The aerial parts of plants were lyophilized and kept at −20 ̊C. Male Wistar rats (180 ± 20 g) were purchased from Tehran Pasteur Institute (Iran) and acclimated to our laboratory animal facilities for at least one week before the start of the experiments. During this period, the animals were maintained on a natural light/dark cycle at 20 ̊C ± 2 ̊C and given food and tap water ad libitum. The extent of liver damage was evaluated based on morphological changes in liver sections stained with hematoxylin and eosin (H & E) using standard techniques. The comparison between the means of treatments and control group was performed using Student’s t-test.
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