Abstract
Ethanol extract of Pisonia aculeata (EPA) was evaluated for hepatoprotective and antioxidant activities in rats. The plant extract (250 and 500 mg/kg, p.o.) showed a remarkable hepatoprotective and antioxidant activity against carbon tetrachloride (CCl4)induced hepatotoxicity as judged from the serum marker enzymes and antioxidant levels in liver tissues. CCl4-induced a significant rise in aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total bilirubin, gamma glutamate transpeptidase (GGTP), lipid peroxidase (LPO) with a reduction of total protein, superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx) and glutathione S-transferase (GST). Treatment of rats with different doses of plant extract (250 and 500 mg/kg) significantly (P<0.001) altered serum marker enzymes and antioxidant levels to near normal against CCl4-treated rats. The activity of the extract at dose of 500 mg/kg was comparable to the standard drug, silymarin (50 mg/kg, p.o.). Histopathological changes of liver sample
Highlights
The liver is the key organ regulating homeostasis in the body
For the acute oral toxicity studies, the extract treated animals were observed for mortality up to 48 h
The levels of serum AST, ALT, alkaline phosphatase (ALP), total bilirubin, gamma glutamate transpeptidase (GGTP) were markedly elevated and that of protein decreased in CCl4 treated animals, indicating liver damage
Summary
The liver is the key organ regulating homeostasis in the body. It is involved with almost all the biochemical pathways related to growth, fight against disease, nutrient supply, energy provision and reproduction [1]. Results indicate the hepatoprotective and antioxidant properties of P. aculeata against CCl4-induced hepatotoxicity in rats. The present study is aimed to evaluate the hepatoprotective and antioxidant activity of ethanol extract of the leaves of Pisonia aculeata against CCl4-induced hepatotoxicity in rats. The levels of serum AST, ALT, ALP, total bilirubin, GGTP were markedly elevated and that of protein decreased in CCl4 treated animals, indicating liver damage.
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