Abstract
Ethanolic extract of the roots of C. spinarum was evaluated for hepatoprotective and anti-oxidant activities in rats. Oral pre-treatment with ethanolic extract (100, 200 and 400 mg/kg) showed significant hepatoprotective activity against CCl4 and paracetamol-induced hepatotoxicity by decreasing the activities of bilirubin and lipid peroxidation, and significant increase in the levels of uric acid, glutathione, super oxide dismutase, catalase and protein in a dose dependent manner, which was confirmed by the decrease in liver wet weight and histopathological examination. The extract possessed strong anti-oxidant activity. This suggests that the hepatoprotective activity of C. spinarum is possibly attributed to its free radical scavenging properties.
Highlights
Excessive production of reactive oxygen species (ROS) plays an important role in the pathogenesis and progression of various diseases involving different organs (Visioli et al, 2000)
There was no mortality amongst the graded dose groups of rats and was found to be safe up to 2 g/kg body weight of extract in rats
There was a significant elevation in the levels of serum marker enzymes like SGOT, SGPT and SALP content of CCl4/PCM intoxicated animals
Summary
Excessive production of reactive oxygen species (ROS) plays an important role in the pathogenesis and progression of various diseases involving different organs (Visioli et al, 2000). Liver disorders are mainly caused by toxic chemicals, excessive consumption of alcohol, infections and autoimmune disorders. Carbon tetrachloride and paracetamol being converted into reactive oxidative metabolites by hepatic microsomal enzymatic system, which causes hepatotoxicity (Brent and Rumack, 1993). The CCU and paracetamol induced acute models have been used to assess hepatoprotective activity. The extract of the plant possesses cardiotonic (Vohra and De, 1963) and antipyretic activity (Hegde and Joshi, 2010). The other related species like C. carandas was proved for its hepatoprotective activity (Hegde and Joshi, 2009)
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