Abstract
Ethanol extracts from the bark of <em>Dipterocarpus turbinatus</em> (EEDT) was evaluated for its hepatoprotective activity by paracetamol and carbon tetrachloride induced hepatotoxicity in rats. Hepatotoxicity was done by using carbon tetra chloride (2ml/kg) and paracetamol (3gm/kg) in rats. 200mg/kg and 400mg/kg of ethanol extracts of <em>D. turbinatus</em> (EEDT) was used as test drugs while silymarin (50mg/kg) used as a standard. Blood was collected by retro orbital pluxes and various biochemical parameters were evaluated related to liver disorder. Various parameters like SGOT, SGPT, ALP, cholesterol, serum bilirubin and levels significantly decreased with the dose dependence manner for EEDT as compared to paracetamol and CCl<sub>4</sub> induced hepatotoxicity in rats. Total protein level was significantly increasing to test drug treated group as compared to the toxic control. Anti oxidant potency of drug was determined by various in-vitro methods and the drug extracts have shown positive results. Therefore, we conclude that it can be used for the treatment of hepatic damage where anti oxidant property is supported for its hepatoprotective activity.
Highlights
3Department of Pharmacognosy, Prime College of Pharmacy, Erattayal, Kodumbu, Ipomoea reniformis Chaos is claimed in Indian traditional medical practice to be useful in the tPreaaltamkkenatdo-f 6ep7i8le5p5sy1,aKnedrala, India neurological disorders
Pretreatment effect of methanolic extract of Ipomoea reniformis on epilepsy and psychosis was evaluated in rodents using standard procedures
Percentage inhibition was calculated and the activity was expressed as an inhibition concentration 50 (IC50)
Summary
Paracetamol and Silymarin were procured from the Micro Lab Ltd., India. Standard biochemical kits {Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT), Serum Alkaline Phosphate (ALP), Bilirubin, Protein kits} were procured form Agappe diagnostics Ltd, Kerala, India. DPPH was procured from Hi Media Mumbai. All other reagents for the study were procured from SD fine lab, Mumbai, India. Remi research centrifuge was used for centrifugation purpose. Mispa excel semi autoanalyzer made of Agappe diagnostic Ltd., Kerala, India and double beam UV-Visible spectrophotometer of Lab India, were used for various analyses. Powdered dried bark of 500 g was extracted up to exhaustion with petroleum ether, chloroform, and ethanol (70%) using soxhlet apparatus. Ethanol extracts (18% w/w) obtained was dried under controlled temperature and was selected for the study
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