Abstract
The effects of polyphenol-containing hepatoprotectors of plant origin, i.e., an extract of the Russian thistle and silymarin, on liver metabolism after paracetamol-induced damage were studied in rats. Both hepatoprotectors decreased the signs of paracetamol hepatotoxicity and promoted recovery of the major functions of the liver. Russian thistle extract and to a lesser extent silymarin prevented the formation of lipid peroxidation products, i.e., diene conjugates, Schiff bases, and malondialdehyde, in the liver, produced reductions in blood aminotransferases, y-glutamyltranspeptidase, acid and alkaline phosphatases, and phospholipase A levels, decreased the total bilirubin concentration, and activated the detoxification of bilirubin, phenols, and ammonia.
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