Abstract
Traditional system of medicine recommends various hepatoprotective agents and preparations to treat hepatic disorders. Polyherbal formulations F1 and F2 were developed for treatment of liver disorders by exploiting the knowledge of traditional system of medicine and evaluated for hepatoprotective activity using acute liver toxicity models of CCl4 and Paracetamol induced liver damage in rats. Th e rats were monitored for morphological changes in liver, biochemical parameter Serum Glutamate Oxaloacetate Transaminase, Serum Glutamate Pyruvate Transaminase, Serum Alkaline Phosphatase, and Serum bilirubin, histopathological studies, and pentobarbitone sleeping time. Both of these formulations F1 and F2 showed signifi cant hepatoprotective activity at dose of 400 mg/kg, which was comparable to silymarin at 6 mg/kg. Formulations F1 and F2 are eff ective both as prophylactic and therapeutic in experimental liver damage. Biochemical parameters showed better results for formulation F2 but morphological, pentobarbitone sleeping time and hisptopathological observation were similar for both the groups. Key words: CCl4 induced toxicity, paracetamol induced toxicity, polyherbal formulations, traditional system of medicine
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