Hepatoprotective activity of methanolic extract of &lt;i&gt;Malva parviflora&lt;/i&gt; against paracetamol-induced hepatotoxicity in mice

Tauqeer Hussain Mallhi,Muhammad Ali,Khizar Abbas,Yusra Habib Khan,Mohammad Saleem,Muhammad Imran Qadir

doi:10.3329/bjp.v9i3.19105

Abstract

Malva parviflora (cheeseweed) is traditionally used as hepatoprotective. The current study was conducted to determine its hepatoprotective activity of aqueous methanolic extract of whole plant. Two doses of plant (250 mg/kg and 500 mg/kg) were administered in paracetamol intoxicated mice and results were compared with silymarin. Observational parameters were ALT, AST, ALP and total bilirubin. The results showed that the extract of M. parviflora produced significant (p<0.001) reduction in liver enzymes and total bilirubin. Results were supported by histopathological investigation, phytochemical screening and detection of hepatoprotective constituents (kaempferol and apigenin) by HPLC. So, the current study showed that aqueous methanolic extract of M. parviflora possesses hepatoprotective activity.

Highlights

Almost 80% people all over the word depend upon traditional medicines to cure their major and minor ailments
Group II served as paracetamol control, receiving paracetamol p.o. 250 mg/kg dissolved in water for 7 days
At the 8th day, blood samples were collected to estimate ALT, AST, ALP and total bilirubin; and livers from animals were separated for histopathological examination (Ali et al, 2013)

Summary

Introduction

Almost 80% people all over the word depend upon traditional medicines to cure their major and minor ailments. The problem of resistance and tolerance to the existing drugs has created a decreased efficacy of these drugs in use. Many plants have been identified as hepatoprotective like Trianthema decandra (Balamurugan and Muthusamy, 2008), Cocculus hirsutus (Thakare et al, 2009), Carica papaya (Sadeque and Begum, 2010), Carissa spinarum (Hegde and Joshi, 2010), Convolvulus arvensis (Ali et al, 2013), Dodonaea viscosa (Khan et al, 2013), Trichodesma sedgwickianum (Saboo et al, 2013), OfIpomoea staphylina (Bag and Mumtaz, 2013), Khamira Gaozaban Ambri Jadwar Ood Saleeb Wala (Akhtar et al, 2013), Cestrum nocturnum (Qadir et al, 2014a), Viola odorata (Qadir et al, 2014b), Chenopodium murale (Saleem et al, 2014) and Morus nigra (Mallhi et al, 2014)

Methods

Results

Conclusion