Hepatoprotective activity of methanolic extract of Barleria montana leaves in ethanol treated rats

Abstract

ObjectiveThe present study was undertaken to investigate the protective effect and possible mechanism of methanolic extract of Barleria montana (BM) on ethanol-induced rat hepatic injury. MethodThis respective activity was assessed through monitoring liver function tests through the measurement of triglycerides, cholesterol, total protein, total bilirubin, serum enzymes like SGOT and SGPT and in vivo antioxidant parameters like lipid peroxidase, Superoxide dismutase(SOD) and catalase,. Further, hepatic tissues were also subjected to histopathological studies. ResultPretreatment of BM methanolic extract (500mg/kg) reduced the fatty liver symptoms and significantly (p<0.001) inhibited the increase of respective serum enzyme levels. ConclusionsThe results of the present study indicated that BM methanolic extract possess hepatoprotective effects which could act as an effective treatment for acute hepatic diseases.