Hepatoprotective Activity of Hydroalcohilic Extract of Annona squamosa Seeds

Abstract

Ethnopharmacological Relevance: Traditionally, Annona Sqamosa Linn. has been used for treatment of cancer, diabetes, microbial infection, cardiac disease, jaundice and other liver related disorder. Hence the current work aims to explore the hepatoprotective of the Annona Sqamosa (AS) seeds. Aim of the study: The main objective of study is to evaluate hepatoprotective activity of the hydroalcoholic extract of seeds of Annona Squamosa Linn. using the carbon tetrachloride induced liver toxicity in rats. Material and methods: The activity was evaluated against carbon tetrachloride induced hepatotoxicity by measuring the levels of serum enzymes such as SGOT, ALP, SGPT and total bilirubin for liver function tests. Six groups of rats were used (n=6) and administered orally once daily with normal saline (normal control), carbon tetrachloride (toxic control), or ASE (100, 200, and 400 mg/kg) for 7 days, followed by the hepatotoxicity induction. Results: The extract showed significant hepatoprotective activity at 100 mg/kg, 200 mg/kg, and 400mg /kg b.w by decreasing the levels of SGOT, SGPT, ALP and total bilirubin as compared to toxic control group. Conclusions: The hydroalcoholic ASE extract have potential of liver protection which could be attributed for further investigation